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OWNER GUIDE · ANYWHERE IN THE US

How to open a medical or dental practice

Seven stages from idea to opening day for a practice, with the federal steps linked and the state and local steps explained.

Updated September 30, 2026 · Federal steps checked against official agency pages

A starting point, not legal advice. Federal steps link to the agency that sets them. Steps marked “Check locally” are set by your state, county or city, and they differ from place to place: we tell you who to ask and link to an official directory. Confirm what applies to you before you rely on it.
STAGE 1

Concept and numbers

Test the idea and the budget before you commit.

  1. OpeningIQ tip

    Draft your startup budget and break-even

    Use your own numbers to see how much you need and what sales cover your costs. Revisit it as quotes come in.

    Try Opening Economics free →

  2. OpeningIQ tip

    Check that your name is available

    Search your state’s business name records and the free federal trademark search before you print signs. This is research, not legal clearance for your practice’s name.

    Search federal trademarks ↗

  3. OpeningIQ tip

    Talk to a free small business adviser

    Small Business Development Centers and SCORE mentors offer free or low-cost counseling near you, including help with plans, budgets and local requirements.

    Find help near you ↗

STAGE 2

Business setup

Register the business and its taxes.

  1. Official step

    Choose your business structure

    Sole proprietorships, LLCs, corporations and partnerships differ in liability and taxes. The SBA’s guide compares them; an accountant or lawyer can help you decide.

    U.S. Small Business Administration ↗

  2. Check locally

    Register your business with your state

    LLCs, corporations, partnerships and nonprofits register with the state where they do business, and need a registered agent in that state. Sole proprietors may not need to register.

    Who to ask: Your state

    Find your state’s registration office ↗

  3. Check locally

    If you’ll use a different name, register it

    A “doing business as” name is registered with your state, county or city, depending on where you are.

    Who to ask: Your state, county or city

    How DBA registration works ↗

  4. Official step

    Get a federal EIN if you need one

    An EIN is needed if you hire employees or operate as a corporation or partnership. It is free from the IRS; be wary of sites that charge for one.

    Internal Revenue Service ↗

  5. Check locally

    Register for state taxes

    Your state’s revenue department tells you which tax accounts you need, such as any state taxes that apply to your practice. Some cities and counties have their own taxes too.

    Who to ask: Your state revenue department

    State tax registration ↗

  6. Check locally

    Ask about a city or county business license

    Many cities and counties require a general business license or registration in addition to state licenses. Ask your city or county business licensing office.

    Who to ask: Your city or county

    About licenses and permits ↗

STAGE 3

Your site

Find a location where your business is allowed.

  1. Check locally

    Confirm zoning allows a practice at the address

    Zoning can restrict or ban some kinds of businesses in an area. Check with your city’s planning or zoning office before you sign a lease.

    Who to ask: Your city or county planning office

    Choosing a location ↗

  2. OpeningIQ tip

    Review your lease or ownership papers

    Make sure the lease allows your use, and check who pays for build-out and required upgrades. Consider having a professional review it; OpeningIQ can’t give legal advice.

  3. Official step

    Plan for accessibility

    Businesses open to the public must follow the ADA. New construction and alterations must be accessible, and barriers in existing spaces must be removed where that’s readily achievable. Small businesses may qualify for a tax credit.

    U.S. Department of Justice (ADA) ↗

STAGE 4

Plans, permits and build-out

Get the approvals to build out and prepare the space.

  1. Check locally

    If you’re renovating, get building permits

    Build-outs and renovations generally need permits from your city or county building department, and some need plan review first. Ask before work starts.

    Who to ask: Your city or county building department

    About licenses and permits ↗

  2. Check locally

    Ask whether you need a certificate of occupancy

    Many places require a certificate of occupancy, or a similar approval, before a new tenant or a new use opens. Your building department can tell you.

    Who to ask: Your city or county building department

    About licenses and permits ↗

  3. Check locally

    Ask the fire department about inspections

    Ask your local fire department or fire marshal whether your space needs an inspection or permit before you open, for example for occupancy limits and exits.

    Who to ask: Your local fire department

    About licenses and permits ↗

  4. Check locally

    If you’ll put up an exterior sign

    Ask your city or county whether your sign needs a permit before you order it.

    Who to ask: Your city or county

    About licenses and permits ↗

STAGE 5

Licenses

Get the licenses that let you open.

  1. Check locally

    Confirm every clinician is licensed in your state

    Physicians, dentists, nurses and other clinicians need licenses from the state where they practice. Check with your state’s medical, dental or nursing board.

    Who to ask: Your state licensing boards

    Look up licenses by state ↗

  2. Check locally

    Ask whether the practice needs a state facility license

    Some practice types, such as ambulatory surgery centers, need a license from the state health department, and some states require approval before certain facilities open. Ask before you commit to a site.

    Who to ask: Your state health department

    Find your state health department ↗

  3. Official step

    Get NPIs for the practice and each clinician

    Health care providers apply for a free National Provider Identifier through NPPES. The practice and each individual clinician have their own.

    Centers for Medicare & Medicaid Services ↗

  4. Official step

    If you’ll handle controlled substances, register with DEA

    Practitioners need state authority first, and a separate DEA registration for each principal place of practice where controlled substances are handled.

    Drug Enforcement Administration ↗

  5. Official step

    If you’ll run lab tests, get a CLIA certificate

    Testing human specimens, including simple tests, needs a CLIA certificate. Apply with form CMS-116 through your state agency.

    Centers for Medicare & Medicaid Services ↗

  6. Official step

    If you’ll bill Medicare, enroll in PECOS

    Get your NPI first, then enroll through PECOS, Medicare’s online enrollment system. An application fee may apply.

    Centers for Medicare & Medicaid Services ↗

  7. OpeningIQ tip

    Start insurance credentialing early

    Credentialing with Medicaid and private insurers takes time. Start once you have your NPIs and licenses.

STAGE 6

Get ready to open

Cover people, insurance and suppliers.

  1. Official step

    Set up HIPAA privacy and security

    Providers that bill or share health information electronically, such as doctors, dentists and clinics, are HIPAA covered entities and must protect patient information.

    U.S. Department of Health and Human Services ↗

  2. Check locally

    If you’ll hire, register as an employer with your state

    States run unemployment insurance tax, and states with an income tax also require withholding. Your state’s labor and revenue departments set up employer accounts.

    Who to ask: Your state labor and revenue departments

    State tax registration ↗

  3. Official step

    If you’ll hire, set up federal payroll taxes

    Withhold federal income tax using each employee’s Form W-4, pay Social Security and Medicare taxes, and pay federal unemployment (FUTA) tax, which isn’t withheld from pay.

    Internal Revenue Service ↗

  4. Official step

    Complete Form I-9 for every hire

    Employers verify each new employee’s identity and authorization to work on Form I-9 and keep it on file.

    U.S. Citizenship and Immigration Services ↗

  5. Official step

    Report new hires to your state

    Report each new employee to your state’s new hire directory within 20 days of hiring; some states require it sooner.

    U.S. Department of Health and Human Services ↗

  6. Official step

    Get workers’ compensation insurance

    Most states require workers’ compensation insurance once you have employees, and the rules vary by state.

    U.S. Small Business Administration ↗

  7. Official step

    Put up required workplace posters

    Which federal posters you need depends on the laws that cover you; the Labor Department’s free Poster Advisor tells you. States have their own posters too.

    U.S. Department of Labor ↗

  8. Official step

    Set up an exposure control plan

    If staff could be exposed to blood or other infectious material, OSHA requires an exposure control plan with protective equipment, training and hepatitis B vaccination.

    Occupational Safety and Health Administration ↗

  9. OpeningIQ tip

    Arrange business insurance

    Ask an insurance broker what coverage your lease, lender and licenses call for, including professional liability (malpractice) coverage. This is an OpeningIQ suggestion, not an agency requirement.

    Types of business insurance ↗

  10. OpeningIQ tip

    Line up equipment, records software and suppliers

    Choose practice-management and records software that supports privacy and billing needs. Get quotes early; your budget should guide the choices.

  11. OpeningIQ tip

    Check every approval is in hand

    Gather your licenses, NPIs, registrations and certificate of occupancy in one place, and confirm each matches your address and business name.

STAGE 7

Open and stay current

Keep licenses, permits and filings current.

  1. OpeningIQ tip

    Keep licenses and registrations current

    Put every renewal on your calendar, including state licenses, DEA and CLIA if you have them, and keep your NPPES and enrollment records up to date when anything changes.

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